Rheostats, not switches: Nuclear receptor dosage tunes somatic-to-iPSC reprogramming

Nuclear receptors are modular transcription factors regulated by ligands, chromatin context, and expression level. Wang et al. 2026, in this issue of Stem Cell Reports show that Rora controls OKS-mediated reprogramming in a dose-dependent manner: moderate expression enhances iPSC formation, while high levels inhibit it, linking quantitative Rora control to immune and WNT signaling during cell fate conversion.