Degree of Enzymatic Hydrolysis Determines Tolerogenic Efficacy: Partial Hydrolysis of Ovalbumin Suppresses Th2 Responses and Mast Cell Activation
family genes in the gut. This study demonstrates that extensive enzymatic cleavage, despite enhancing safety, may compromise efficacy by destroying essential immunogenic signals. Consequently, optimizing the degree of hydrolysis is crucial for developing safe and effective hypoallergenic formulas for oral tolerance induction.
Authors
- Xuanyi Meng (ORCID: https://orcid.org/0000-0002-0314-2077)
- Ping Tong (ORCID: https://orcid.org/0000-0002-0298-6411)
- Xiaoya Wang (ORCID: https://orcid.org/0000-0002-7500-2428)
- Fangfang Min
- Hongbing Chen
- Zhongliang Wang
- Xin Li
- Qiang Shi
- Nan Chen
- Shuangyan Zheng
Institutions
- Jiangxi University of Traditional Chinese Medicine (CN)
- Deutsches Historisches Institut Washington (US)
- Nanchang University (CN)
- Institute of Food Science & Technology (GB)
- State Key Laboratory of Food Science and Technology (CN)
Publication Details
- Journal
- Journal of Agricultural and Food Chemistry
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1021/acs.jafc.6c00626
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Jiangxi Province