Metabolic–photoimmunotherapy: A Shikonin–NIR-I photosensitizer nanoplatform reprograms glycolysis to potentiate phototherapy-induced antitumor immunity in hepatocellular carcinoma
T cell infiltration, and, crucially, inducing robust long-term immune memory. This rationally designed strategy provides a promising and translationally relevant approach for eradicating primary tumors and preventing post-treatment relapse in HCC.
Authors
- Jiongshan Zhang (ORCID: https://orcid.org/0000-0001-8775-2536)
- Huijiao Fu
- Yilan Dai
- Weilong Yang
- Huiyi Lu
- Ling Lin
- Yan Chen
- Feng Fang
- Zhiqiang Yu
- Hao Hu
- Qiuxia Chen
- Xue Liu
Institutions
- Sun Yat-sen University (CN)
- First People's Hospital of Foshan (CN)
- First Affiliated Hospital of Guangzhou University of Chinese Medicine (CN)
- Eye & ENT Hospital of Fudan University (CN)
- Zhujiang Hospital (CN)
- Dongguan People’s Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Third Affiliated Hospital of Sun Yat-sen University (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1016/j.mtbio.2026.103084
- Primary Topic
- Photodynamic Therapy Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Association of Integrative Medicine
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province