Leaflet Modification for Bicuspid Aortic Valve Tricuspidalization Enabling Implantation of Larger Transcatheter Heart Valves

Severe raphe calcification in bicuspid aortic valve (BAV) remains a major challenge for transcatheter aortic valve replacement (TAVR), often leading to asymmetric valve expansion, residual gradients, and suboptimal durability. We report a case of intentional leaflet modification to enable functional "tricuspidalization" of BAV anatomy and facilitate implantation of a larger transcatheter heart valve (THV). In a 76-year-old high-risk patient with severe aortic stenosis and heavily calcified raphe, a modified UNICORN electrosurgical laceration technique was used to split the fused cusps. This approach allowed annular-based sizing and successful implantation of a 23-mm THV, with optimal expansion, no residual gradient, and preserved coronary access. This strategy may improve TAVR outcomes in selected BAV patients. Larger studies are warranted to confirm the safety, reproducibility, and clinical efficacy of this approach.

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Publication Details

Journal
The American Journal of Cardiology
Published
2026-04-03
DOI
https://doi.org/10.1016/j.amjcard.2026.03.062
Primary Topic
Cardiac Valve Diseases and Treatments
Type
article
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article

Leaflet Modification for Bicuspid Aortic Valve Tricuspidalization Enabling Implantation of Larger Transcatheter Heart Valves

Antonella Cecchetto, Luca Nai Fovino, Tommaso Fabris, Giuseppe Tarantini
The American Journal of Cardiology
Cardiac Valve Diseases and Treatments
article

Leaflet Modification for Bicuspid Aortic Valve Tricuspidalization Enabling Implantation of Larger Transcatheter Heart Valves

Antonella Cecchetto, Luca Nai Fovino, Tommaso Fabris, Giuseppe Tarantini
article en

Abstract

Severe raphe calcification in bicuspid aortic valve (BAV) remains a major challenge for transcatheter aortic valve replacement (TAVR), often leading to asymmetric valve expansion, residual gradients, and suboptimal durability. We report a case of intentional leaflet modification to enable functional "tricuspidalization" of BAV anatomy and facilitate implantation of a larger transcatheter heart valve (THV). In a 76-year-old high-risk patient with severe aortic stenosis and heavily calcified raphe, a modified UNICORN electrosurgical laceration technique was used to split the fused cusps. This approach allowed annular-based sizing and successful implantation of a 23-mm THV, with optimal expansion, no residual gradient, and preserved coronary access. This strategy may improve TAVR outcomes in selected BAV patients. Larger studies are warranted to confirm the safety, reproducibility, and clinical efficacy of this approach.

The American Journal of CardiologyVol. 269
University of Padua (IT)
Zero hunger
Openalex Percentile: Top 34%
Cardiac Valve Diseases and Treatments
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