Recombinant Mycobacterium smegmatis producing a functional M. tuberculosis ESX-1 system is protective in the murine model of bovine TB without sensitization to tuberculin
T-cell and IFN-γ independent and will require further investigation. Nevertheless, our results indicate MSX-1 is an effective bTB vaccine that deserves further development for use in livestock.
Authors
- Jeffrey M. Chen (ORCID: https://orcid.org/0000-0001-8431-3802)
- Nirajan Niroula (ORCID: https://orcid.org/0000-0002-3243-0131)
- Dielle E. Whitecross
- Sherin McDonald
- Slim Zriba
Institutions
- Saskatchewan Health Authority (CA)
- Vancouver Infectious Diseases Centre (CA)
Publication Details
- Journal
- Vaccine
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.vaccine.2026.128545
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beef Cattle Research Council