Capicua mediates interleukin-2 withdrawal–induced death of activated CD8+ T cells

T cells, resulting in their increase in the later phase of infection. Our findings suggest that CIC plays a vital role in CWID through a noncanonical mechanism, providing new insights into how the immune system limits uncontrolled inflammation and immunopathology.

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Publication Details

Journal
Cell Insight
Published
2026-04-03
DOI
https://doi.org/10.1016/j.cellin.2026.100323
Primary Topic
T-cell and B-cell Immunology
Type
article
Field-Weighted Citation Impact
0.00

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article

Capicua mediates interleukin-2 withdrawal–induced death of activated CD8+ T cells

Wen-Hao Hang, Ye Xu, Jun-Ge Shi, Zhen-Wu Ma et al.
Cell Insight
T-cell and B-cell Immunology
article

Capicua mediates interleukin-2 withdrawal–induced death of activated CD8+ T cells

Wen-Hao Hang, Ye Xu, Jun-Ge Shi, Zhen-Wu Ma, Xin-Yue Zhang, Shu Li
article en

Abstract

T cells, resulting in their increase in the later phase of infection. Our findings suggest that CIC plays a vital role in CWID through a noncanonical mechanism, providing new insights into how the immune system limits uncontrolled inflammation and immunopathology.

Cell InsightVol. 5(3)
Wuhan University (CN), Wuhan Institute of Virology (CN), Zhongnan Hospital of Wuhan University (CN)
Ministry of Science and Technology of the People's Republic of China, Wuhan University, Fundamental Research Funds for the Central Universities
Good health and well-being
Openalex Percentile: Top 27%
T-cell and B-cell Immunology
DOIOpen Access PDFOpenAlex
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