Migrasome-transported PTGES amplifies the PGE2 cascade in SPP1+ macrophages to drive oral leukoplakia carcinogenesis
macrophage phenotype and promotes migration and proliferation. These findings uncover an unexplored migrasome-dependent immunomodulatory mechanism in OLK carcinogenesis and suggest migrasomal PTGES as a promising biomarker for early OSCC detection and a potential therapeutic target.
Authors
- Mingjing Jiang (ORCID: https://orcid.org/0000-0002-9578-8552)
- Gang Zhou
Institutions
- Wuhan University (CN)
Publication Details
- Journal
- Nature Communications
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1038/s41467-026-70824-2
- Primary Topic
- Oral Health Pathology and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China