LZTS2 Emerges as a Regulator of Craniofacial Development and Modulator of DYRK1A
Background: was used to test the role of LZTS2 in craniofacial development and its functional relationship with DYRK1A. Results: revealed striking overlap, consistent with a potential functional interaction between these genes in humans. Conclusions: These findings identify Lzts2 as a previously unrecognized regulator of craniofacial development and support a functional interaction with Dyrk1a during embryogenesis. Modulating LZTS2 or related regulatory partners may provide a strategy to selectively tune DYRK1A-dependent developmental pathways.
Authors
- Santiago Lima (ORCID: https://orcid.org/0000-0002-6949-7962)
- L. Litovchick
- Nicole Cheng (ORCID: https://orcid.org/0009-0000-2050-4298)
- Amanda J. G. Dickinson
Institutions
- Virginia Commonwealth University (US)
- University of Toledo (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-02
- DOI
- https://doi.org/10.64898/2026.03.31.715576
- Primary Topic
- Down syndrome and intellectual disability research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute of Dental and Craniofacial Research