An overview of the time-resolved capabilities and sample setup modularity at CoSAXS

CoSAXS is a multipurpose SAXS instrument located at the 3 GeV ring of MAX IV Laboratory in Sweden. This instrument provides a versatile platform for conducting Small-Angle X-ray scattering (SAXS) experiments on a wide range of research fields. With an extensive pool of sample environments, CoSAXS enables the application of multiple techniques and complex experiments on solid and solution samples. To accomodate the high demand and facilitate the rapid exchange of sample setups, a standardized mounting system has been implemented and additive manufacturing techniques are utilized for fast and efficient prototyping and production of customized sample holders. Furthermore, CoSAXS is equipped with advanced sample environments, such as the setup for milliseconds Time-Resolved SAXS-WAXS experiments in solution (TR-XSS). Among other studies it has been used in non-reversible protein reactions after laser activation of caged compounds.

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Publication Details

Journal
JACOW
Published
2026-04-02
DOI
https://doi.org/10.18429/jacow-medsi2025-tup06
Primary Topic
Enzyme Structure and Function
Type
article
Field-Weighted Citation Impact
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An overview of the time-resolved capabilities and sample setup modularity at CoSAXS

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JACOW
Enzyme Structure and Function
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An overview of the time-resolved capabilities and sample setup modularity at CoSAXS

Jackson Luís da Silva, Ann E. Terry, Byungnam Ahn, Tomás S. Plivelic, Roberto Appio, Vanessa Da Silva, Pablo Mota-Santiago, Fatima Herranz Trillo
article en

Abstract

CoSAXS is a multipurpose SAXS instrument located at the 3 GeV ring of MAX IV Laboratory in Sweden. This instrument provides a versatile platform for conducting Small-Angle X-ray scattering (SAXS) experiments on a wide range of research fields. With an extensive pool of sample environments, CoSAXS enables the application of multiple techniques and complex experiments on solid and solution samples. To accomodate the high demand and facilitate the rapid exchange of sample setups, a standardized mounting system has been implemented and additive manufacturing techniques are utilized for fast and efficient prototyping and production of customized sample holders. Furthermore, CoSAXS is equipped with advanced sample environments, such as the setup for milliseconds Time-Resolved SAXS-WAXS experiments in solution (TR-XSS). Among other studies it has been used in non-reversible protein reactions after laser activation of caged compounds.

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Enzyme Structure and Function
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An overview of the time-resolved capabilities and sample setup modularity at CoSAXS — Jackson Luís da Silva, Ann E. Terry, et al. · JACOW (2026) | TGRS Research Map | TGRS