Integrating Weighted Gene Co-Expression Network and Differential Expression Analyses to Unveil the Role of RNA m6A Methylation Regulators in Idiopathic Parkinson’s Disease in Latin America

transcripts. To our knowledge, this study represents the first integrative transcriptomic evaluation of m6A-associated regulatory patterns in early iPD within a Latin American population. Collectively, our findings suggest that selective m6A-associated transcriptional network alterations may contribute to the systemic molecular signatures observed in early iPD, warranting further validation in larger and mechanistically oriented studies.

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Publication Details

Journal
Life
Published
2026-04-01
DOI
https://doi.org/10.3390/life16040592
Primary Topic
RNA modifications and cancer
Type
article
Field-Weighted Citation Impact
0.00

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article

Integrating Weighted Gene Co-Expression Network and Differential Expression Analyses to Unveil the Role of RNA m6A Methylation Regulators in Idiopathic Parkinson’s Disease in Latin America

Francisco Leiva, B Morales, Luís Constandil, Rodrigo Vidal et al.
Life
RNA modifications and cancer
article

Integrating Weighted Gene Co-Expression Network and Differential Expression Analyses to Unveil the Role of RNA m6A Methylation Regulators in Idiopathic Parkinson’s Disease in Latin America

Francisco Leiva, B Morales, Luís Constandil, Rodrigo Vidal, Rene L. Vidal, Pedro Chana-Cuevas
article en

Abstract

transcripts. To our knowledge, this study represents the first integrative transcriptomic evaluation of m6A-associated regulatory patterns in early iPD within a Latin American population. Collectively, our findings suggest that selective m6A-associated transcriptional network alterations may contribute to the systemic molecular signatures observed in early iPD, warranting further validation in larger and mechanistically oriented studies.

LifeVol. 16(4)
Universidad de Santiago de Chile (CL), Universidad Mayor (CL), University of Chile (CL)
Michael J. Fox Foundation for Parkinson's Research, Yale University, Universidad de Santiago de Chile, Agencia Nacional de Investigación y Desarrollo, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Openalex Percentile: Top 37%
RNA modifications and cancer
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