High risk of hypoxemic COVID-19 pneumonia in myasthenia gravis patients with type I IFN autoantibodies
=0.0019). Thymoma is, thus, associated with a higher risk of producing AAN-I-IFN, and these autoantibodies are associated with a higher risk of developing life-threatening COVID-19 pneumonia in patients with MG.
Authors
- Annie Verschueren (ORCID: https://orcid.org/0000-0003-1266-9062)
- Rozen Le Panse (ORCID: https://orcid.org/0000-0001-7522-5974)
- Mélodie Aubart (ORCID: https://orcid.org/0000-0002-4383-7930)
- Jessica N. Peel (ORCID: https://orcid.org/0000-0002-1894-8882)
- Sarah Souvannanorath (ORCID: https://orcid.org/0000-0001-7986-0983)
- Clémence Basse (ORCID: https://orcid.org/0000-0002-0523-0310)
- Kévin Bigaut (ORCID: https://orcid.org/0000-0002-5176-580X)
- Audrey V. Parent (ORCID: https://orcid.org/0000-0003-4506-6268)
- Maria da Penha Ananias Morita (ORCID: https://orcid.org/0000-0002-8087-5936)
- Guilhem Solé (ORCID: https://orcid.org/0000-0001-9599-6573)
- Nils Landegren (ORCID: https://orcid.org/0000-0002-6163-9540)
- Frédérique Truffault (ORCID: https://orcid.org/0000-0003-1284-8634)
- Sophie Demeret (ORCID: https://orcid.org/0000-0002-0523-6472)
- Eduardo de Paula Estephan (ORCID: https://orcid.org/0000-0002-6807-1951)
- Annemarie Hübers (ORCID: https://orcid.org/0000-0002-3088-0366)
- Romain Fort (ORCID: https://orcid.org/0000-0003-0773-3883)
- Lucy Bizien (ORCID: https://orcid.org/0000-0001-9163-9122)
- Jérémie Rosain (ORCID: https://orcid.org/0000-0002-2822-161X)
- Sylvie Pons (ORCID: https://orcid.org/0000-0002-6286-0546)
- Ludivine Kouton
- Mélanie Migaud (ORCID: https://orcid.org/0000-0003-3062-1214)
- Amine Rachdi (ORCID: https://orcid.org/0000-0001-6220-5974)
- Marie‐Alexandra Alyanakian (ORCID: https://orcid.org/0000-0002-9902-9027)
- Emmanuelle Jouanguy (ORCID: https://orcid.org/0000-0002-7358-9157)
- Astrid Marchal (ORCID: https://orcid.org/0000-0003-0648-8126)
- Axel Cederholm (ORCID: https://orcid.org/0009-0006-5973-9637)
- Alexis Maillard (ORCID: https://orcid.org/0000-0002-7165-4103)
- Kahina Saker (ORCID: https://orcid.org/0000-0001-8825-5400)
- Vivien Béziat (ORCID: https://orcid.org/0000-0002-4020-824X)
- Cyril Gitiaux (ORCID: https://orcid.org/0000-0002-2190-6843)
- Shahram Attarian (ORCID: https://orcid.org/0000-0002-7211-4694)
- Karolina Hankiewicz
- Rafael León López
- Cécile Cauquil
- Rocío-Nur Villar-Quiles
- Aleksandra Nadaj Pakleza
- S Sassi
- Samir Belal
- Marie‐Céline Fleury
- Thierry Jo Molina
- Zakaria Saied
- Florent Wallet
- Joseph L L DeRisi
- Quentin Philipot
- Isabelle Desguerre
- Amouri Rim
- Jean-Laurent Casanova
- Emilie Rocher
- Emmanuel Faure
- Nicholas Heming
- Celine Tard
- Aaron Bodansky
- Mark S Anderson
- Catherine Biggs
- Edmar Zanoteli
- Guillaume Nicolas
- Qiang Pan-Hammarstrom
- Aurelie Cobat
- Tom Le Voyer
- Djillali Annane
- Aude-Marie Grapperon
- Pascal Laforet
- Nicolas Girard
- Laurent Abel
- Anne Puel
- Paul Bastard
Institutions
- Faculdade de Medicina de São José do Rio Preto (BR)
- Howard Hughes Medical Institute (US)
- University of British Columbia (CA)
- Université de Bordeaux (FR)
- Inserm (FR)
- National Grid (United States) (US)
- University of California, San Francisco (US)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Université Paris Cité (FR)
- Aix-Marseille Université (FR)
- Université Paris-Saclay (FR)
- Science for Life Laboratory (SE)
- Karolinska Institutet (SE)
- Centre Hospitalier Universitaire de Lille (FR)
- Sorbonne Université (FR)
- Hospital for Sick Children Pediatric Center (US)
- Düsseldorf University Hospital (DE)
- Hôpital de la Croix-Rousse (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hospices Civils de Lyon (FR)
- Bordeaux Population Health (FR)
- Hôpital Pellegrin (FR)
- Hôpital Lyon Sud (FR)
- Institut de Myologie (FR)
- Pitié-Salpêtrière Hospital (FR)
- Hospital Universitario Reina Sofía (ES)
- Maison de la Simulation (FR)
- Hôpitaux Universitaires Henri-Mondor (FR)
- Hôpital Raymond-Poincaré (FR)
- Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (BR)
- Centre Hospitalier Saint-Denis (FR)
- Hôpital Charles-Foix (FR)
- BC Children's Hospital (CA)
- National Institute of Neurology Mongi-Ben Hamida (TN)
- Bicêtre Hospital (FR)
- Institut des Maladies Génétiques Imagine (FR)
- Centre de Recherche en Myologie
- Heinrich Heine University Düsseldorf (DE)
- Université Lille Nord de France (FR)
- Tunis El Manar University (TN)
- Université de Strasbourg (FR)
- University of San Francisco (US)
- Institut Curie (FR)
- Rockefeller University (US)
- Egis (France) (FR)
Publication Details
- Journal
- medRxiv
- Published
- 2026-04-02
- DOI
- https://doi.org/10.64898/2026.03.27.26349525
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fisher Center for Alzheimer's Research Foundation
- St. Giles Foundation
- Fondation du Souffle
- Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation
- Georgia Clinical and Translational Science Alliance
- Institut des maladies génétiques Imagine
- European Commission
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Fondation pour la Recherche Médicale
- Stavros Niarchos Foundation
- Vetenskapsrådet
- National Institutes of Health
- National Center for Advancing Translational Sciences