Bio‐Polymer Supported Heterogeneous Copper Catalysts for Azide‐Alkyne Cycloaddition Reactions: An Overview

ABSTRACT The pursuit of effective, selective, and environmentally benign chemical transformation has significantly impacted the advancement of sustainable synthesis. By considering this ‘click’ reaction or specifically the Copper catalyzed Azide–Alkyne Cycloaddition (CuAAC) has gained significant attention due to its remarkable regioselectivity, atom economy, and operational simplicity. Use of biopolymer‐based supports in heterogeneous CuAAC reactions enhances the sustainability, catalytic efficiency, and reusability while aligning with the principles of green chemistry. This review provides a comprehensive overview of all biopolymer‐supported copper catalytic systems for click reactions, encompassing cellulose, chitosan, alginate, lignin, starch, fibroin, gelatin, and other polysaccharide composites. Additionally, this review discusses recent advancement in the design, synthesis, and characteristics of the catalyst as well as the influence and performance of these systems under the key parameters such as reaction temperature, solvent system, catalyst loading, and recycling.