Functional profiling of somatostatin receptors identifies somatostatin receptor subtype 2 as a vulnerability in Succinate Dehydrogenase SDHB-deficient pheochromocytomas and paragangliomas
and clear receptor internalization upon BIM-23120 treatment. Molecular analysis revealed a generalized dephosphorylation affecting key proliferation, growth and cell survival pathways in response to BIM-23120 (unlike when treating with octreotide). Altogether, our results provide novel information on the status of the somatostatin system in PPGL and identify new potential therapeutic tools selectively targeting somatostatin receptors on this refractory tumor.
Authors
- María Ángeles Gálvez-Moreno
- María Trinidad Moreno-Montilla (ORCID: https://orcid.org/0000-0002-5942-7768)
- Luisa M. Botella (ORCID: https://orcid.org/0000-0002-6310-2245)
- Ricardo Blazquez-Encinas
- Víctor García-Vioque (ORCID: https://orcid.org/0000-0002-4979-0168)
- Michael D. Culler (ORCID: https://orcid.org/0000-0001-5168-8739)
- Aura Dulceida Herrera-Martinez
- Alejandro Ibañez-Costa
- Justo P. Castaño (ORCID: https://orcid.org/0000-0002-3145-7287)
- Mercedes Robledo (ORCID: https://orcid.org/0000-0001-6256-5902)
- Federica Mangili (ORCID: https://orcid.org/0000-0002-2758-5841)
- Ester Arroba
- Sergio Pedraza-Arevalo
- Esther Rivero-Cortés
- Anne Barlier
Institutions
- Inserm (FR)
- Aix-Marseille Université (FR)
- Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition (ES)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Spanish National Cancer Research Centre (ES)
- Instituto Maimónides de Investigación Biomédica de Córdoba (ES)
- Centro de Investigación Biomédica en Red (ES)
- Hospital Universitario Reina Sofía (ES)
- Centro de Investigaciones Biológicas Margarita Salas (ES)
- University of Córdoba (ES)
- Cordoba University (US)
Publication Details
- Journal
- Molecular Biomedicine
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1186/s43556-026-00440-5
- Primary Topic
- Adrenal and Paraganglionic Tumors
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Novartis
- Paradifference foundation
- Society for Endocrinology
- Ministerio de Ciencia e Innovación
- Universidad de Córdoba
- Junta de Andalucía
- Instituto de Salud Carlos III
- Agencia Estatal de Investigación
- Ministerio de Universidades