The Trouble with Trials: Systematic Review and Meta-Analysis of Randomized Controlled Trials Comparing Stereotactic Radiosurgery, Whole Brain Radiotherapy, and Observation for Resected Metastatic Brain Disease
: Even among RCTs, the best available evidence regarding adjuvant treatment for oligometastatic brain disease is heterogeneous, imprecise, and inconclusive. WBRT improves SBC and IC, but not OS. SRS may decrease CD risk, which requires validation in double-blind RCTs incorporating precise neurocognitive metrics.
Authors
- Shearwood McClelland (ORCID: https://orcid.org/0000-0001-7951-9726)
- Avital Perry (ORCID: https://orcid.org/0000-0003-0231-7346)
- Tyler Gunter
- Baylee Stevens
- Khalil St Brice
- Christopher S. Graffeo
- Victor M. Lu
Institutions
- University of Miami (US)
- Oklahoma City University (US)
- Sheba Medical Center (IL)
- University of Oklahoma Health Sciences Center (US)
- University of Oklahoma (US)
Publication Details
- Journal
- Cancers
- Published
- 2026-04-02
- DOI
- https://doi.org/10.3390/cancers18071149
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00