Peptide signaling in the paraventricular thalamus contributes to disrupted adult reward behaviors after early-life adversity
deletion in TRAPed-PVT cells restores typical reward behaviors in ELA mice. Our results provide insight into the developmental origin of mental illness and identify potentially powerful molecular targets for prevention or mitigation of the consequences of ELA on reward behaviors germane to human mental illness.
Authors
- Matthew T. Birnie (ORCID: https://orcid.org/0000-0003-3964-5247)
- Heidi Yahan Liang (ORCID: https://orcid.org/0000-0002-6190-9723)
- Roshae C. Roberts (ORCID: https://orcid.org/0009-0001-9544-8048)
- Madison R. Tetzlaff (ORCID: https://orcid.org/0000-0002-4158-6162)
- Cassandra L. Kooiker
- Annabel K. Short (ORCID: https://orcid.org/0000-0001-9654-3197)
- Yuncai Chen (ORCID: https://orcid.org/0000-0002-4862-3704)
- Magdalena Gantuz (ORCID: https://orcid.org/0000-0003-3201-8080)
- Ali Mortazavi (ORCID: https://orcid.org/0009-0008-0609-0680)
- M P Hardy (ORCID: https://orcid.org/0000-0001-6774-5902)
- Ryan Weber (ORCID: https://orcid.org/0000-0003-2044-9297)
- Amalia Floriou-Servou
- Tallie Z. Baram
Institutions
- University of California, Irvine (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-02
- DOI
- https://doi.org/10.64898/2026.03.31.715695
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Fondation pour la Recherche Médicale
- National Institutes of Health