A sensory system for mating in octopus
Sensory systems for mate recognition maintain species boundaries and influence diversification. Thus, uncovering how molecules and receptors evolve to mediate this critical function is essential to understanding biodiversity. Male octopuses use a specialized arm called the hectocotylus to identify females and navigate their internal organs to reach the oviduct and deliver sperm. Here, we discovered that the hectocotylus is a dual sensory and mating organ that uses contact-dependent chemosensation of progesterone, a conserved ovarian hormone. We identified chemotactile receptors for progesterone and resolved the structural basis for their evolution from ancestral neurotransmitter receptors and subsequent expansion and tuning across cephalopods. These findings reveal principles by which sensory innovations shape reproductive behavior and suggest mechanisms for how sensory evolution contributes to the diversification of life.
Authors
- Nicholas W. Bellono (ORCID: https://orcid.org/0000-0002-0829-9436)
- Erik Lindahl (ORCID: https://orcid.org/0000-0002-2734-2794)
- Pablo S. Villar (ORCID: https://orcid.org/0000-0003-3462-8798)
- Emma L. Berdan (ORCID: https://orcid.org/0000-0002-6435-4604)
- Arpita Kulkarni (ORCID: https://orcid.org/0000-0003-0775-8044)
- Tatiana Shugaeva (ORCID: https://orcid.org/0009-0001-8147-0762)
- Sam Reiter (ORCID: https://orcid.org/0000-0001-6879-663X)
- Ryan Hibbs (ORCID: https://orcid.org/0000-0003-4283-1147)
- Makoto Hiroi
- Giovanni Masucci
Institutions
- Linköping University (SE)
- Harvard University (US)
- Okinawa Institute of Science and Technology Graduate University (JP)
- University of Illinois Urbana-Champaign (US)
- Stockholm University (SE)
- Science for Life Laboratory (SE)
- University of California San Diego (US)
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Science
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1126/science.aec9652
- Citations
- 2
- Primary Topic
- Cephalopods and Marine Biology
- Type
- article
- Field-Weighted Citation Impact
- 75.84