Steady-state epithelial apical flatness is characterized by MLCK morphodynamics and asynchronous Ca <sup>2+</sup> oscillations, but not by underlying ECM geometry
imaging reveals an asynchronous calcium flux across a confluent epithelium. Our results highlight that apical/basal cellular surfaces may not be tightly coordinated, but rather independently regulated. This study provides a new paradigm for how apical flatness is regulated at steady state.
Authors
- Lisa L. Hua (ORCID: https://orcid.org/0009-0008-2975-2384)
- Emerson Herrmann (ORCID: https://orcid.org/0009-0001-2361-4713)
- Jeanette Hyer
- Takashi Mikawa (ORCID: https://orcid.org/0000-0003-1051-8260)
- Hao Wu
Institutions
- Sonoma State University (US)
- Bay Institute (US)
- Mission Bio (United States) (US)
Publication Details
- Journal
- Molecular Biology of the Cell
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1091/mbc.e25-12-0583
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00