<i>Tetrastigma Hemsleyanum</i> Polysaccharide Suppresses Triple‐Negative Breast Cancer by Disrupting the Hippo‐YAP/TEAD4‐PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation
flux in vitro, and-importantly-blocks metastasis in patient-derived organoids, zebrafish xenografts, and two syngeneic mouse models at non-toxic doses. Multi-omics analyses and rescue assays confirm the TEAD4-PDIA4 axis as the core functional module. Our findings establish THP as a first-in-class, natural-product-based therapeutic that disrupts ER-stress addiction in metastatic TNBC by targeting the Hippo-YAP/TEAD4-PDIA4 axis.
Authors
- Hongmeng Su (ORCID: https://orcid.org/0000-0002-3175-4097)
- Yini Shang
- Can Li (ORCID: https://orcid.org/0000-0002-9301-7850)
- Yafei Li (ORCID: https://orcid.org/0000-0002-0010-5940)
- Huaixi Zhang
- Zhishan Ding
- Youxue Zhang
- Wentao Si
- Wei Jiang
Institutions
- Zhejiang Chinese Medical University (CN)
- Fujian Medical University (CN)
- Harbin Medical University (CN)
- Third Affiliated Hospital of Harbin Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Advanced Science
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1002/advs.202519006
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province