Cardiac myofibril networks induce shear stress
). Simulations produce unique deformations for geometries informed by myofibril orientations, displaying internal rotation and off-axis deformations. Moreover, anisotropy generates shear stresses distinct from the uniaxial case, demonstrating spatial relationships that balance shear across the cell and a correlation between shear stress and z-disc orientation. These findings highlight the impact of myofibril networks on forces during cell contraction.
Authors
- Christian Pinali (ORCID: https://orcid.org/0000-0001-9815-6940)
- Vijay Rajagopal (ORCID: https://orcid.org/0000-0002-5509-402X)
- D. J. Collins
- L. A. Murray
- A. P. Quinn
Institutions
- Australian Research Council (AU)
- The University of Melbourne (AU)
- Manchester Academic Health Science Centre (GB)
- University of Manchester (GB)
- Melbourne Health (AU)
Publication Details
- Journal
- npj Systems Biology and Applications
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1038/s41540-026-00696-1
- Primary Topic
- Cardiomyopathy and Myosin Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- British Heart Foundation
- Royal Society
- University of Melbourne
- Australian Research Council
- National Health and Medical Research Council