CAV2 Modulates Cetuximab Sensitivity in HNSCC via Ubiquitin-Mediated Disruption of the PACT-PKR Axis
In conclusion, these findings establish CAV2 as a critical regulator of HNSCC progression and Cetuximab sensitivity via post-translational modulation of the PACT-PKR axis. Targeting the CAV2/PACT/PKR axis may therefore represent a promising therapeutic strategy to potentiate the efficacy of EGFR-targeted therapy in patients with HNSCC.
Authors
- Dongqi Yuan
- Shenge Liu
- Yafei Wang
- Peng Chen
Institutions
- Tianjin Medical University Cancer Institute and Hospital (CN)
- Affiliated Hospital of Chengde Medical College (CN)
- Chengde Medical University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2026-04-02
- DOI
- https://doi.org/10.3390/cancers18071148
- Primary Topic
- Caveolin-1 and cellular processes
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China