IL-22 from enteroendocrine cells promotes early-life gut motility in zebrafish through the microbiota
. IL-22-deficient mice also had impaired gut motility and reduced ghrelin expression in early life, indicating a conserved function. Thus, before immune system maturation, enteroendocrine cells regulate early-life gut function by controlling the microbiota through IL-22.
Authors
- Emiliano Marachlian (ORCID: https://orcid.org/0000-0001-9826-5696)
- Patricia Diabangouaya
- Germán Sumbre (ORCID: https://orcid.org/0000-0003-4436-6840)
- Gwendoline Gros
- Alvaro Banderas (ORCID: https://orcid.org/0000-0002-9970-2971)
- Sylvia Brugman (ORCID: https://orcid.org/0000-0001-9955-0552)
- Aya Mikdache
- Georges Lutfalla (ORCID: https://orcid.org/0000-0002-6591-7894)
- Akshai Janardhana Kurup (ORCID: https://orcid.org/0000-0002-5468-2794)
- Pedro P. Hernández (ORCID: https://orcid.org/0000-0002-2873-4298)
- Fabian Guendel
- Yazan Salloum (ORCID: https://orcid.org/0009-0005-5181-4666)
- Pascal Hersen (ORCID: https://orcid.org/0000-0003-2379-4280)
- Soraya Rabahi
- Vincenzo Di Donato (ORCID: https://orcid.org/0000-0002-4080-9301)
- Filippo Del Bene (ORCID: https://orcid.org/0000-0001-8551-2846)
- Carmen Gloria Feijóo (ORCID: https://orcid.org/0000-0003-1128-403X)
- Jos Boekhorst (ORCID: https://orcid.org/0000-0002-4807-7838)
- Camila Garcia-Baudino
- Keinis Quintero-Castillo (ORCID: https://orcid.org/0009-0002-1797-738X)
- Ignacio Medina-Yáñez
- Lucie Maurin
- Jessica Riou-Ramon
- Jean-Pierre Levraud
- Gerard Eberl
Institutions
- Centre National de la Recherche Scientifique (FR)
- Institut de la Vision (FR)
- Inserm (FR)
- Institut Pasteur (FR)
- Université de Montpellier (FR)
- Université Paris Cité (FR)
- Université Paris Sciences et Lettres (FR)
- Université Paris-Saclay (FR)
- École Normale Supérieure - PSL (FR)
- Sorbonne Université (FR)
- Institut des Neurosciences Paris-Saclay (FR)
- Leibniz-Institute for New Materials (DE)
- Universidad Andrés Bello (CL)
- Institut de Biologie de l'École Normale Supérieure (FR)
- Center for Climate and Resilience Research (CL)
- Wageningen University & Research (NL)
Publication Details
- Journal
- Science
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1126/science.adr1707
- Primary Topic
- Aquaculture disease management and microbiota
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Horizon 2020 Framework Programme
- European Research Council