Relationship Between Sperm DNA Fragmentation and Composite Morphological Indices: A Multivariable Analysis

: Composite sperm morphological indices were not independently associated with sperm DNA fragmentation after adjusting for quantitative semen parameters in the present analytical framework. These findings suggest that structural abnormalities and genomic instability may capture complementary aspects of male infertility rather than representing interchangeable markers. SDF assessment may therefore provide complementary diagnostic information beyond morphology-based evaluation, particularly in assisted reproductive contexts.

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Publication Details

Journal
Medicina
Published
2026-04-02
DOI
https://doi.org/10.3390/medicina62040679
Primary Topic
Sperm and Testicular Function
Type
article
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0.00
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article

Relationship Between Sperm DNA Fragmentation and Composite Morphological Indices: A Multivariable Analysis

M. Șandor, Cristina Aur, Petronela Naghi, Liana Ștefan et al.
Medicina
Sperm and Testicular Function
article

Relationship Between Sperm DNA Fragmentation and Composite Morphological Indices: A Multivariable Analysis

M. Șandor, Cristina Aur, Petronela Naghi, Liana Ștefan, Veliscu Andreea Carp, Diana Mocuța, Liliana Sachelarie
article en

Abstract

: Composite sperm morphological indices were not independently associated with sperm DNA fragmentation after adjusting for quantitative semen parameters in the present analytical framework. These findings suggest that structural abnormalities and genomic instability may capture complementary aspects of male infertility rather than representing interchangeable markers. SDF assessment may therefore provide complementary diagnostic information beyond morphology-based evaluation, particularly in assisted reproductive contexts.

MedicinaVol. 62(4)
Carol Davila University of Medicine and Pharmacy (RO), University of Oradea (RO), Clinical Emergency Hospital Bucharest (RO), Apollonia University (RO), County Hospital (GB)
Openalex Percentile: Top 37%
Sperm and Testicular Function
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