Factors Associated with Reduced Clinical Response in Adult ADHD: The Role of Alcohol and Cannabis Use Disorders and Autism Spectrum Disorder
In adults with ADHD treated in routine clinical practice, alcohol and cannabis use disorders were associated with a reduced likelihood of achieving clinically meaningful improvement under routine pharmacological care, whereas autism spectrum disorder showed a trend toward lower response that was not stable enough to support firm conclusions. These findings should be considered exploratory given the retrospective design, limited sample size, and lack of systematic treatment exposure measures.
Authors
- Irene Matarese (ORCID: https://orcid.org/0000-0001-8405-5516)
- Beniamino Tripodi (ORCID: https://orcid.org/0000-0003-2184-5240)
- Giulio Perugi (ORCID: https://orcid.org/0000-0001-5556-1858)
- Alessandro Bellini
- Francesco De Dominicis (ORCID: https://orcid.org/0009-0002-5428-9471)
- Filippo Della Rocca (ORCID: https://orcid.org/0000-0002-7935-3524)
- Manuel Glauco Carbone (ORCID: https://orcid.org/0000-0002-7457-6008)
- Claudia Tagliarini (ORCID: https://orcid.org/0000-0001-5599-045X)
- Roberta Rizzato
- Angelo G. I. Maremmani
- Icro Maremmani
Institutions
- University of Pisa (IT)
- University of Insubria (IT)
- American Society of Addiction Medicine (US)
- Saint Camillus International University of Health and Medical Sciences (IT)
- Ospedale di Spoleto (IT)
- CTO Andrea Alesini (IT)
- Azienda Ospedaliera Ospedale Maggiore (IT)
Publication Details
- Journal
- Journal of Clinical Medicine
- Published
- 2026-04-02
- DOI
- https://doi.org/10.3390/jcm15072688
- Primary Topic
- Attention Deficit Hyperactivity Disorder
- Type
- article
- Field-Weighted Citation Impact
- 0.00