Treatment efficacy and adherence in patients with chronic heart failure according to the chronic heart failure registry in the Tyumen region

The objective of the study was to evaluate achievement of target doses of essential medications (ACE inhibitors/ARBs/ARNIs, beta-blockers, MRA and SGLT2) and patient adherence to therapy. We analyzed medication prescriptions depending on CHF phenotype and left ventricular ejection fraction (LVEF), as well as dynamics of clinical and laboratory parameters (LVEF and NT-proBNP). There was low rate of achievement of target doses for beta-blockers and ACE inhibitors/ARBs/ARNIs (<20% of patients), while MRAs were prescribed at optimal doses in more than 90% of cases. Only 50.6% of patients demonstrated high adherence to therapy. Repeated assessment of LVEF and NTproBNP was performed in only a subset of patients. However, patients on optimal medical therapy showed improvements of LVEF and decrease of NTproBNP. Therefore, it is necessary to increase physician awareness, improve compliance with clinical guidelines and intensify follow-up to improve treatment adherence and prognosis in patients with CHF.