Photoactivated probiotic micro-reactor synchronizes STING/TLRs agonists to spatiotemporally synergize antitumor immunotherapy
T cells responses. This subsequently inhibits tumor growth, relapse, and metastasis in the murine 4T1 tumor model. Collectively, our work introduces the bacteria-based system that uses near-infrared light to dual-release immunotherapeutics for systemic anti-tumor immunity, opening new avenues for precise and effective cancer immunotherapy.
Authors
- Xi Yu (ORCID: https://orcid.org/0000-0002-7724-8317)
- Yuzhi Qiu
- Yidi Liu (ORCID: https://orcid.org/0000-0002-8071-1464)
- Yunting Liu
- Xiangliang Yang
- Yanhong Zhu
- Yan Zhang
- Sihan Chen
Institutions
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-04-02
- DOI
- https://doi.org/10.1186/s12951-026-04300-w
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China