Cellular Processes and Forces Shaping the Embryo: Lessons from C. elegans
embryonic morphogenesis. Building on past reviews in the field, we analyze dorsal intercalation, ventral enclosure, and axis extension, with a focus on how forces impinge on cellular processes and serve to coordinate morphogenesis across adjacent tissues through mechanotransduction. We also discuss how different forms of cellular rosettes contribute to ventral patterning and head morphogenesis, which had not been discussed in previous reviews. Throughout, we highlight how the reciprocal feedback mechanisms between molecular processes and mechanical forces, as well as cell material properties, shape the embryo.
Authors
- Michel Labouesse (ORCID: https://orcid.org/0000-0001-7995-5843)
- Zoe Tesone
- Teresa Ferraro (ORCID: https://orcid.org/0009-0005-7050-2246)
- Jeff Hardin (ORCID: https://orcid.org/0000-0001-7399-6580)
- Flora Llense (ORCID: https://orcid.org/0009-0000-3043-9397)
- Jonathon Heier
Institutions
- University of Wisconsin–Madison (US)
- Sorbonne Université (FR)
- Institut de Biologie Paris-Seine (FR)
Publication Details
- Journal
- Cells
- Published
- 2026-04-02
- DOI
- https://doi.org/10.3390/cells15070645
- Primary Topic
- Cellular Mechanics and Interactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Agence Nationale de la Recherche
- European Research Council