Dietary restriction mitigates 5-fluorouracil-induced thrombocytopenia in aged mice via mitochondrial potentiation in hematopoietic stem cells and megakaryocyte progenitors
) showed a lower incidence of CIT following 5-FU treatment than those with higher BMI. Together, we show that short-term DR significantly mitigates CIT and that targeting mitochondria may represent a novel therapeutic strategy for CIT in elderly cancer patients.
Authors
- Zhendong Tao (ORCID: https://orcid.org/0000-0002-4188-8603)
- Rongrong Qiu
- Xingxing Qiu
- Duozhuang Tang (ORCID: https://orcid.org/0000-0002-7725-205X)
- Zhiyang Chen (ORCID: https://orcid.org/0009-0002-8460-2633)
- Liu Zhang (ORCID: https://orcid.org/0000-0001-9923-260X)
- Qiao Wang (ORCID: https://orcid.org/0000-0003-0648-9399)
- Si Tao (ORCID: https://orcid.org/0000-0001-6956-8516)
- Qiang Zhan
- Siyao He
- Shaotong Zhang
Institutions
- Jinan University (CN)
- Capital Medical University (CN)
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- First Affiliated Hospital of Jiangxi Medical College (CN)
- Integrated Chinese Medicine (China) (HK)
Publication Details
- Journal
- Stem Cell Reports
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.stemcr.2026.102869
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Jiangxi Province