Tissue and Isoform-Specific Effects of Platelet-Derived Growth Factor on Neonatal-Derived Dermal and Fetal-Derived Lung Fibroblast Profibrotic Functions
< 0.05) compared to lung fibroblasts. In summary, PDGF modulates fibroblast functions in a tissue-specific manner, with PDGF-BB driving profibrotic processes in dermal fibroblasts through high PDGFRβ expression and ERK1/2 signalling. Further research is needed to explore the benefit of tissue and isoform-specific PDGF inhibition strategies in skin and lung fibrosis.
Authors
- Kevin J. Keen (ORCID: https://orcid.org/0000-0001-5695-0505)
- James V. Dunne
- Raveen Badyal (ORCID: https://orcid.org/0000-0002-1278-3933)
- Tillie-Louise Hackett
- Brandon Kohlen
Institutions
- University of British Columbia (CA)
- University of Northern British Columbia (CA)
- St. Paul's Hospital (CA)
Publication Details
- Journal
- Cells
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3390/cells15070637
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Providence Health Care
- Canada Research Chairs
- Scleroderma Association of British Columbia
- Canadian Institutes of Health Research