Synergistic tissue destruction by Staphylococcus aureus and Staphylococcus epidermidis in a 3D human skin biofilm equivalent
dominated in co-culture, pathogenicity was not dependent on bacterial load. These findings demonstrate synergistic host modulation in polymicrobial staphylococcal biofilms and establish the 3DSE as a physiologically relevant platform for studying skin biofilm infections.
Authors
- Andreas J. Roth (ORCID: https://orcid.org/0000-0002-1145-955X)
- Norman Lippmann (ORCID: https://orcid.org/0000-0002-6420-426X)
- Frank Siemers
- Laura Kursawe (ORCID: https://orcid.org/0000-0002-1532-3334)
- Philipp Kobbe (ORCID: https://orcid.org/0009-0008-8020-0788)
- Olga Kurow (ORCID: https://orcid.org/0000-0001-9831-0194)
- Judith Kikhney (ORCID: https://orcid.org/0000-0002-4849-7947)
- Annette Moter (ORCID: https://orcid.org/0000-0003-1318-5780)
- Nadine Dietze
- Nguyen Ngoc-Huyen (ORCID: https://orcid.org/0009-0009-4986-8314)
- Christina Pempe
- Stefan Langer
- Rima Nuwayhid
Institutions
- University Hospital Leipzig (DE)
- BG Klinikum Bergmannstrost Halle (DE)
- 108 Military Central Hospital (VN)
- Martin Luther University Halle-Wittenberg (DE)
- Leipzig University (DE)
Publication Details
- Journal
- Biofilm
- Published
- 2026-04-03
- DOI
- https://doi.org/10.1016/j.bioflm.2026.100361
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Gesetzliche Unfallversicherung
- Universität Leipzig