Oral Inflammatory Lesions and Bone Turnover Biomarkers (Dkk-1 and TRAP-5B) in Patients with ENT Cancer: A Radiological and Clinical Case–Control Study

: Patients with ENT cancer exhibited significantly altered systemic bone turnover biomarker profiles, characterized by increased TRAP-5B and decreased Dkk-1 levels. Clinically, these patients also presented a higher prevalence of periodontal pockets and periapical lesions, whereas carious lesions were more frequently detected in healthy individuals. The combined radiological and biochemical findings contribute to a better understanding of oral-systemic interactions in oncologic patients and highlight the importance of comprehensive dental evaluation prior to oncologic therapy.