The Immunomodulatory Effects of Porcupine Bezoar on Cyclophosphamide-Induced Immunosuppression in Rats
: This study demonstrates that PB can effectively counteract CTX-induced immunosuppression in rats. This immunomodulatory effect is linked to changes in the gut microbiota and the regulation of specific metabolic pathways. These findings provide a scientific basis for the potential use of PB as an immunoadjuvant therapy, offering new insights into the mechanisms of traditional medicines.
Authors
- Qinqiang Long (ORCID: https://orcid.org/0000-0001-9036-8535)
- Jie Li (ORCID: https://orcid.org/0000-0002-4366-7724)
- Xiao-Qing Sim
- Zhipeng Chen
- Kien-Seng Lim
- Song Lei
- Wenbo Gao
- Xue Xiao
Institutions
- Guangdong Pharmaceutical University (CN)
- Sunway University (MY)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3390/ph19040563
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 0.00