Longitudinal Assessment of Hematologic and Immunonutritional Biomarkers from Treatment Initiation to Progression in Metastatic Colorectal Cancer
: The clinical value of inflammatory hematologic indices in mCRC appears to derive primarily from their longitudinal dynamics rather than single absolute measurements. SII, in particular, may serve as a marker of therapy-induced modulation of systemic inflammation, especially in patients with preserved immunonutritional reserve. Integration of dynamic inflammatory indices into routine clinical monitoring could enhance early identification of biological progression and improve risk stratification in mCRC.
Authors
- Ana Tečić Vuger (ORCID: https://orcid.org/0000-0003-2203-161X)
- Robert Šeparović (ORCID: https://orcid.org/0000-0002-4002-2699)
- Sanja Langer (ORCID: https://orcid.org/0000-0002-6350-9694)
- Mihaela Gaće (ORCID: https://orcid.org/0009-0004-5470-7850)
- Ljubica Vazdar (ORCID: https://orcid.org/0000-0001-6264-3675)
- M Vrbancic
- Iva Andrašek
- Zvjezdana Špacir Prskalo
- L Mayer
- Ljiljana Mayer
- Ines Sever
Institutions
- University Hospital Centre Zagreb (HR)
- University of Zagreb (HR)
- Juraj Dobrila University of Pula (HR)
- Zabok General Hospital (HR)
- Catholic University of Croatia (HR)
- Sisters of Charity Hospital (HR)
- University of Osijek (HR)
Publication Details
- Journal
- Biomedicines
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3390/biomedicines14040799
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00