Sustainable Design and DoE-Based Optimization of Polymeric Systems for FDM 3D-Printed Indomethacin Amorphous Solid Dispersions
: This study demonstrates that electrical energy consumption can be systematically embedded as a quantitative design variable in pharmaceutical process optimization. The proposed dual-stage DoE strategy establishes a rational framework for developing 3D-printed ASD dosage forms that balance molecular performance and environmental efficiency.
Authors
- Afroditi Kapourani (ORCID: https://orcid.org/0000-0001-5025-1519)
- Christos Vlachokostas (ORCID: https://orcid.org/0000-0001-6399-248X)
- Panagiotis Barmpalexis (ORCID: https://orcid.org/0000-0002-6765-512X)
- Christos Cholevas (ORCID: https://orcid.org/0000-0002-1517-8691)
- Ioannis Pantazos
Institutions
- Aristotle University of Thessaloniki (GR)
- Centre for Research and Technology Hellas (GR)
Publication Details
- Journal
- Pharmaceuticals
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3390/ph19040562
- Primary Topic
- 3D Printing in Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission