2,3-Bisphosphoglycerate Mutase (BPGM), a Metabolic Player Shaping Stress-Adaptive Transcriptional States in Clear Cell Renal Cell Carcinoma
silencing and Vorinostat treatment triggered distinct transcriptional programs. While HDAC inhibition induced widespread transcriptional changes, BPGM loss elicited a focused stress-associated response, consistent with activation of the unfolded protein response, increased lipid peroxidation, and induction of ER stress-associated genes. Our data identify BPGM as a metabolic player contributing to stress-adaptive transcriptional states in ccRCC and suggest that targeting metabolic stress adaptation may complement epigenetic strategies in renal cancer.
Authors
- Vera A. Kulow (ORCID: https://orcid.org/0000-0002-4226-6697)
- Philipp Nils Becker (ORCID: https://orcid.org/0000-0002-8607-7185)
- Robert Labes (ORCID: https://orcid.org/0000-0001-8179-1315)
- Michael Fähling (ORCID: https://orcid.org/0000-0003-1079-5049)
- Bianca Nitzsche (ORCID: https://orcid.org/0000-0001-7916-3344)
- Kameliya Roegner (ORCID: https://orcid.org/0000-0002-2487-3696)
- Adrian Schreiber (ORCID: https://orcid.org/0000-0003-1244-6379)
- Michael Höpfner (ORCID: https://orcid.org/0000-0003-0785-9451)
- Claudia S. Czopek
- Gohar Ter-Avetisyan
- Anica Loth
- Cem Erdogan
Institutions
- Humboldt-Universität zu Berlin (DE)
Publication Details
- Journal
- Cells
- Published
- 2026-03-31
- DOI
- https://doi.org/10.3390/cells15070633
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Deutsche Forschungsgemeinschaft