Pulmonary microbiota, local inflammation, and tumor progression impact immune checkpoint gene profiles in the lung microenvironment

. Taken together, our study uncovers ICG signatures linked to tumor progression and sheds light on the complex network of microbiota-host immunity interactions within the lung microenvironment. This study lays the groundwork for future mechanistic studies and underscores the significance of microbiota-host immunity interactions for predicting and tracking the response to cancer treatment.

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Publication Details

Journal
Physiological Genomics
Published
2026-04-01
DOI
https://doi.org/10.1152/physiolgenomics.00300.2025
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
0.00

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article

Pulmonary microbiota, local inflammation, and tumor progression impact immune checkpoint gene profiles in the lung microenvironment

Jinshuang Liu, Bo Li, Siwen Zhang, Kun Huang
Physiological Genomics
Cancer Immunotherapy and Biomarkers
article

Pulmonary microbiota, local inflammation, and tumor progression impact immune checkpoint gene profiles in the lung microenvironment

Jinshuang Liu, Bo Li, Siwen Zhang, Kun Huang
article en

Abstract

. Taken together, our study uncovers ICG signatures linked to tumor progression and sheds light on the complex network of microbiota-host immunity interactions within the lung microenvironment. This study lays the groundwork for future mechanistic studies and underscores the significance of microbiota-host immunity interactions for predicting and tracking the response to cancer treatment.

Physiological Genomics
Harbin Normal University (CN), Harbin Medical University (CN), Second Affiliated Hospital of Dalian Medical University (CN), Third Affiliated Hospital of Harbin Medical University (CN), Second Affiliated Hospital of Harbin Medical University (CN)
Beijing Medical Award Foundation
Good health and well-being
Openalex Percentile: Top 29%
Cancer Immunotherapy and Biomarkers
DOISourceOpenAlex
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