STRADA deficiency impairs cortical interneuron development in humans and mice
loss contributes to failed IN migration - the first such report in a developmental, mTOR-associated megalencephaly syndrome - highlighting INs as a therapeutic target for seizure prevention in PMSE. Key Points: mice reveals evidence of early developmental interneuron and cytoskeletal dysfunction We introduce a loss of cortical interneurons as a salient feature of PMSE developmental pathogenesis, potentially contributing to a loss of inhibitory modulationThis is the first study proposing interneuron migration impairment in the developmental pathogenesis of an mTOR-associated megalencephaly syndrome.
Authors
- Ria K. Parikh
- Louis T. Dang (ORCID: https://orcid.org/0000-0003-4853-4952)
- Reana Young-Morrison (ORCID: https://orcid.org/0000-0003-3449-4750)
- Vincent J. Carson (ORCID: https://orcid.org/0000-0002-0402-4849)
- Meghna Pandey
- Sandesh P. Kamdi (ORCID: https://orcid.org/0000-0003-0688-1841)
- Whitney E. Parker
- Philip H. Iffland (ORCID: https://orcid.org/0000-0003-2203-188X)
- Sophie Tran
- Danya A Adams
- Asmaa Hijazi
- ThachVu H Nguyen
Institutions
- University of Maryland, Baltimore (US)
- Clinic for Special Children (US)
- Michigan Medicine (US)
Publication Details
- Journal
- bioRxiv (Cold Spring Harbor Laboratory)
- Published
- 2026-04-01
- DOI
- https://doi.org/10.64898/2026.03.30.715326
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00