Associations of High-Sensitivity Cardiac Troponin T, D-Dimer, and N-Terminal Pro–B-Type Natriuretic Peptide with Subclinical Cardiovascular Dysfunction in the General Population: A Retrospective Cross-Sectional Study

Purpose: The purpose of this study was to analyze the relationship between resting high-sensitive serum cardiac troponin T concentration (hs-cTnT), D-dimer, and N-terminal pro-B-type natriuretic peptide (NT-proBNP), measured outside the clinical context of acute illness, and selected parameters related to subclinical cardiovascular (CV) dysfunction in the general population. Patients and Methods: This retrospective study included patients hospitalized at the Department of Internal Medicine, Angiology and Physical Medicine, Medical University of Silesia, Katowice, Poland, from January 2023 to May 2024. CV system assessment comprised transthoracic echocardiography, Doppler ultrasound of the carotid and lower extremity arteries, pulse wave velocity (PWV) measurement, ankle-brachial index (ABI) measurement, and toe-brachial index (TBI) measurement. Results: = 0.05). Conclusion: hs-cTnT, D-dimer, and NT-proBNP, determined in the absence of acute illness, correlate with selected parameters of subclinical CV dysfunction independently of confounding factors such as age, gender, body mass index, diabetes, hypertension, and smoking.