WFDC21P is essential for G3BP1-mediated RIG-I activation and antitumor immunity in triple-negative breast cancer
T cells but also improves the response to immune checkpoint blockade, thus providing a compelling combination immunotherapy strategy for treating triple-negative breast cancer.
Authors
- Man‐Li Luo (ORCID: https://orcid.org/0000-0002-6435-7303)
- Zhengjie Chen
- Renzhong Liu
- Zean Li
- Yiming Zhao
- Yue Wang
- Na-Na Li
- Yi Wang
- Zheng-Hao Lai
Institutions
- Sun Yat-sen University (CN)
- Hangzhou Normal University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1073/pnas.2532576123
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangdong Province
- National Key Research and Development Program of China