Identification of an Orally Bioavailable Quinoline-Based Small-Molecule Tumor Necrosis Factor α (TNF-α) Inhibitor Featuring a Spirocyclic Scaffold
, a small-molecule TNF-α inhibitor, has the potential to serve as an effective oral therapeutic agent for the treatment of autoimmune diseases.
Authors
- Ping Wei (ORCID: https://orcid.org/0000-0002-3781-3844)
- Boning Wang
- Yuchen Zhang (ORCID: https://orcid.org/0009-0008-9178-7369)
- Pu Chen (ORCID: https://orcid.org/0000-0002-6857-2211)
- Jiayi Xu (ORCID: https://orcid.org/0000-0003-3465-7927)
- Yungen Xu
- Hongfeng Gu (ORCID: https://orcid.org/0009-0004-4385-3430)
- Wanyong He
- Hanxi Xing
- Chunxiang Yin
- Yanan Sun
- Wenbin Zhang
- Yannan Luo
- Jia Gu
- Joshua M. He
- Yao Luo
- Zeren Sun
Institutions
- China Pharmaceutical University (CN)
- Hefei Design and Research Institute of Coal Industry (China) (CN)
- State Key Laboratory of Natural Medicine
- Rice University (US)
Publication Details
- Journal
- Journal of Medicinal Chemistry
- Published
- 2026-03-31
- DOI
- https://doi.org/10.1021/acs.jmedchem.5c03457
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Government of Jiangsu Province