ClpP2 modulates ClpXP assembly to promote multiple pathogenic phenotypes in <i> <i>Pseudomonas aeruginosa</i> </i>
can adaptively modulate ClpXP assembly dynamics to adjust proteolysis and expand its phenotypic versatility. We propose that organisms that encode multiple ClpP subunits can exert finer control over regulated substrate degradation and thereby optimize their display of pathogenic traits that support opportunistic infections.
Authors
- Gina D. Mawla (ORCID: https://orcid.org/0000-0003-0253-0470)
- Jia Jia Zhang
- Arielle J. Weinstein
- Tania A. Baker (ORCID: https://orcid.org/0000-0002-0737-3411)
- Reed Robinson
Institutions
- Massachusetts Institute of Technology (US)
Publication Details
- Journal
- Proceedings of the National Academy of Sciences
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1073/pnas.2532651123
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Life Sciences Research Foundation
- National Institute of Allergy and Infectious Diseases
- Division of Diabetes, Endocrinology, and Metabolic Diseases