B <sub>2</sub> pin <sub>2</sub> -Mediated Cascade Cyclization of 2-Alkenylanilines To Give 2-Difluoromethylthio/seleno-4-Aryl(alkyl)-Quinolines

source for the efficient construction of highly functionalized quinolines. The reliability, practicality, and scalability of this process are fully demonstrated through gram-scale synthesis, late-stage functionalization, and evaluation of its potential antitumor activity.

Authors

Dong Lu
Xiang Gao (ORCID: https://orcid.org/0009-0009-6364-0391)
Jiawei Dong (ORCID: https://orcid.org/0000-0002-7839-6303)
Xinyi Zhang
Jiahe Zou
Jinyao Li
Renhua Qiu

Institutions

Hunan University (CN)
Shanghai Institute of Materia Medica (CN)
Chemo (France) (FR)
State Key Laboratory of Chemobiosensing and Chemometrics (CN)
Xinjiang University (CN)

Publication Details

Journal: Organic Letters
Published: 2026-04-01
DOI: https://doi.org/10.1021/acs.orglett.6c00914
Primary Topic: Fluorine in Organic Chemistry
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Natural Science Foundation of Henan Province
Natural Science Foundation of Xinjiang

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article

B ₂ pin ₂ -Mediated Cascade Cyclization of 2-Alkenylanilines To Give 2-Difluoromethylthio/seleno-4-Aryl(alkyl)-Quinolines

Dong Lu, Xiang Gao, Jiawei Dong, Xinyi Zhang et al.

Apr 1, 2026

Organic Letters

Fluorine in Organic Chemistry

article

B ₂ pin ₂ -Mediated Cascade Cyclization of 2-Alkenylanilines To Give 2-Difluoromethylthio/seleno-4-Aryl(alkyl)-Quinolines

Dong Lu, Xiang Gao, Jiawei Dong, Xinyi Zhang, Jiahe Zou, Jinyao Li, Renhua Qiu

April 1, 2026article en

Abstract

source for the efficient construction of highly functionalized quinolines. The reliability, practicality, and scalability of this process are fully demonstrated through gram-scale synthesis, late-stage functionalization, and evaluation of its potential antitumor activity.

Organic LettersVol. 28(15)

Hunan University (CN), Shanghai Institute of Materia Medica (CN), Chemo (France) (FR), State Key Laboratory of Chemobiosensing and Chemometrics (CN), Xinjiang University (CN)

Natural Science Foundation of Henan Province, Natural Science Foundation of Xinjiang

Openalex Percentile: Top 29%

Fluorine in Organic Chemistry

DOI Source OpenAlex

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B <sub>2</sub> pin <sub>2</sub> -Mediated Cascade Cyclization of 2-Alkenylanilines To Give 2-Difluoromethylthio/seleno-4-Aryl(alkyl)-Quinolines — Dong Lu, Xiang Gao, et al. · Organic Letters (2026) | TGRS Research Map | TGRS