Animal ex-vivo model for the reproduction of the human ascending aorta
) and PWV (3.8 ± 0.6 m/s) values were comparable to native porcine aortas suggesting preserved biomechanics, and differences from typical human values reflected expected interspecies variability rather than model artifacts. The extended porcine AA model accurately reproduces human AA geometry and mechanical response without compromising tissue integrity. The model provides a practical and reproducibleex-vivoplatform forin-vitro testing and development of novel endovascular devices targeting human AA, bridging the gap between bench-top validation and preclinical evaluation.
Authors
- Paolo Bellotti (ORCID: https://orcid.org/0000-0003-4839-8807)
- Nesar A Hasami (ORCID: https://orcid.org/0000-0003-2726-7349)
- Ariel Pascaner (ORCID: https://orcid.org/0000-0002-5236-8339)
- Martina Schembri
- Ferdinando Auricchio (ORCID: https://orcid.org/0000-0002-0064-2201)
- M. Di Giancamillo (ORCID: https://orcid.org/0000-0003-3128-4619)
- Alessandro Caimi (ORCID: https://orcid.org/0000-0003-2856-1347)
- Leonardo Foresti (ORCID: https://orcid.org/0000-0002-7265-3321)
- Jasper F de Kort (ORCID: https://orcid.org/0009-0004-9189-0674)
- Jessica Bassi
- Michele Conti
- Santi Trimarchi
Institutions
- University of Milan (IT)
- University of Pavia (IT)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- IRCCS Policlinico San Donato (IT)
Publication Details
- Journal
- Journal of Biomechanics
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.jbiomech.2026.113283
- Primary Topic
- Aortic Disease and Treatment Approaches
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Research Council