The impact of blood pressure variability and African Caribbean ethnicity on the progression of diabetic kidney disease in type 1 diabetes

AIMS/HYPOTHESIS: Blood pressure variability (BPV) is a risk factor for kidney disease progression in hypertension and type 2 diabetes; however, the role of BPV in kidney disease in type 1 diabetes is unknown. The aim of this study was therefore to determine whether BPV has an impact on kidney disease progression in an ethnically diverse cohort of people with type 1 diabetes. METHODS: , with death as a competing risk. RESULTS: , albuminuria and mean blood pressure in the exposure window. The strongest association was observed for the ARV of SBP (HR 1.54, 95% CI 1.27, 1.87, p<0.001). CONCLUSIONS/INTERPRETATION: In people with type 1 diabetes, SBP and DBP variability are associated with kidney disease progression. Further studies are needed to investigate if BPV is a modifiable risk factor for kidney disease progression.