Reconstituted phospholipid membrane-coated Fe2+-Mg2+ displacement nanoparticles block ferroptotic trigger waves
displacement within 4 h, significantly increasing MUFA-PLs of target cell membrane and enabling efficient Mg/Ce-MOF delivery, over threefold improvement in ferroptosis resistance and redox systems compared to controls, and efficient bone mass enhancement with rapid defect healing in ovariectomized (OVX) mice/rats over 8 weeks. This FTWs-blocking strategy provides a paradigm for treating iron accumulation-related diseases.
Authors
- Xiaoji Luo
- Runhan Zhao (ORCID: https://orcid.org/0000-0002-5681-7568)
- Yanran Huang (ORCID: https://orcid.org/0000-0001-8064-4006)
- Xiaotao Qu (ORCID: https://orcid.org/0000-0002-0237-7915)
- Shanshan Zhang
- Jingtao Xu
- Jun Zhang
- Wenguo Cui
Institutions
- Ruijin Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.bioactmat.2026.03.042
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Chongqing Medical University