SuFEx-Functionalized Pyrroles via Regioselective 1,3-Dipolar Cycloaddition of Münchnones
We have devised a regioselective synthesis of sulfonyl fluoride-functionalized pyrroles via the 1,3-dipolar cycloaddition of münchnones with 1-bromoethene-1-sulfonyl fluoride. The methodology was scalable and could realize the synthesis of a wide variety of functionalized pyrroles. By subjecting the sulfonyl fluoride-functionalized pyrroles to SuFEx conditions, we could generate interesting pyrrole sulfonamides and sulfonates.
Authors
- Jomon Mathew (ORCID: https://orcid.org/0000-0001-9279-6277)
- Jubi John (ORCID: https://orcid.org/0000-0003-0483-2026)
- Sreejith K. Aravindakshan
- Jayalakshmi Achath
- Malu Biju
Institutions
- National Institute for Interdisciplinary Science and Technology (IN)
- NOAA Chemical Sciences Laboratory (US)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1021/acs.orglett.6c01229
- Primary Topic
- Synthesis and Characterization of Pyrroles
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Council of Scientific and Industrial Research, India
- University Grants Commission
- Science and Engineering Research Board