Disruption of Glomerular Map Formation in the Accessory Olfactory System Impairs Chemosensory Processing and Social Behavior

-deficient mice exhibited significantly reduced vomeronasal acuity to chemosignals, which is associated with a loss of male-directed aggression in both male and postpartum female mice. Functional mapping of neural activity revealed attenuated responses in mitral cells of the AOB, as well as in aggression-related brain regions, including the medial amygdala and ventromedial hypothalamus. These findings underscore the critical role of glomerular map integrity in the vomeronasal system for maintaining chemosensory acuity and regulating social behaviors. Furthermore, this study provides insight into how molecular disruptions in sensory neuron connectivity can reshape neural circuits and behavioral outputs.