Ginsenoside-Rh2 inhibits U251 glioma cell migration and invasion via the Gab2/Akt2 pathway

Background: , has shown anti-tumor potential. Gab2, a tyrosine kinase substrate, is implicated in glioma pathogenesis; however, the mechanism by which GS-Rh2 might inhibit glioma cell migration and invasion via the Gab2/Akt2 pathway remains unexplored. Objective: To investigate the effects and mechanisms of GS-Rh2 on glioma cell migration and invasion through the Gab2/Akt2 signaling pathway. Methods: , GS-Rh2 was administered to nude mice bearing U251 or siGab2/U251 intracranial xenografts. HE staining assessed brain invasion, and western blot detected Gab2 and Akt2 expression in tumor tissues. Results: < 0.05). Conclusions: GS-Rh2 inhibits migration and invasion of U251 glioma cells by decreasing Gab2 expression and Akt2 phosphorylation, suggesting that GS-Rh2 targets the Gab2/Akt2 signaling axis.