Downregulation of L-type Ca2+ current in patients with atrial fibrillation results from altered channel gating and disruption of membrane microdomains
BACKGROUND: ). OBJECTIVE: remodeling in chronic AF. METHODS: reduction. RESULTS: . CONCLUSION: downregulation in AF is driven by chamber-specific degradation of membrane structures and loss of functional LTCCs, not offset by increased channel activity. Caveolin-3 is crucial for maintaining functional LTCCs at the sarcolemma.
Authors
- Carla Lucarelli (ORCID: https://orcid.org/0000-0002-5321-1149)
- Cristina E. Molina (ORCID: https://orcid.org/0000-0003-3094-1568)
- Peter Wright (ORCID: https://orcid.org/0000-0002-6504-590X)
- Marina Balycheva
- Claire Poulet (ORCID: https://orcid.org/0000-0002-1063-5830)
- Nadja I. Bork
- Benedict Reilly-O’Donnell (ORCID: https://orcid.org/0000-0003-0183-3701)
- Ivan Diakonov
- Alexey V. Glukhov (ORCID: https://orcid.org/0000-0003-2076-9688)
- Marta Mazzola (ORCID: https://orcid.org/0000-0002-7767-1801)
- Giuseppe Faggian (ORCID: https://orcid.org/0000-0001-5371-5761)
- Viacheslav O. Nikolaev (ORCID: https://orcid.org/0000-0002-7529-5179)
- Sophie Schobesberger (ORCID: https://orcid.org/0000-0001-8268-0019)
- Prakash P Punjabi (ORCID: https://orcid.org/0000-0002-6587-1603)
- Roman Y. Medvedev (ORCID: https://orcid.org/0000-0003-1174-2993)
- Kelly Zhang
- Jose L. Sanchez-Alonso
- Natalia A. Trayanova
- Julia Gorelik
- Anita Alvarez-Laviada
Institutions
- University of Verona (IT)
- Humanitas University (IT)
- University of Wisconsin–Madison (US)
- Johns Hopkins University (US)
- Universität Hamburg (DE)
- Johns Hopkins Medicine (US)
- Lung Institute (US)
- University Medical Center Hamburg-Eppendorf (DE)
- German Centre for Cardiovascular Research (DE)
- Imperial College London (GB)
Publication Details
- Journal
- Heart Rhythm
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1016/j.hrthm.2026.03.1953
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Foundation for the National Institutes of Health
- American Heart Association
- Wellcome Trust
- British Heart Foundation
- Deutsche Forschungsgemeinschaft
- National Institutes of Health