G Protein-Coupled Oestrogen Receptor Actions Targeting the Hallmarks of Cancer in Human Prostate Cells: From Cell Fate to Metabolic Reprogramming
Overall, this study demonstrated that GPER activation affects a broad range of PCa hallmarks. These findings support an anti-cancer role for GPER in PCa and encourage further exploration of its action in regulating metabolism and as a therapeutic target.
Authors
- Patrícia Arinto
- Sara Trindade Correia
- Marília I. Figueira (ORCID: https://orcid.org/0000-0003-0901-9931)
- Tiago M. A. Carvalho (ORCID: https://orcid.org/0000-0001-9095-1413)
- Sílvia Socorro (ORCID: https://orcid.org/0000-0001-8181-488X)
- Rui Henrique (ORCID: https://orcid.org/0000-0003-3171-4666)
- Lara R. S. Fonseca (ORCID: https://orcid.org/0000-0002-8789-4048)
- Henrique J. Cardoso (ORCID: https://orcid.org/0000-0002-5750-2875)
- Adriana O. Santos (ORCID: https://orcid.org/0000-0002-1224-9191)
- Cláudio Jb Maia
Institutions
- University of Beira Interior (PT)
- Universidade do Porto (PT)
- Instituto Português de Oncologia Francisco Gentil (PT)
Publication Details
- Journal
- Cancers
- Published
- 2026-04-01
- DOI
- https://doi.org/10.3390/cancers18071137
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00