Synchronous PET/MR imaging and visualizing penetration of nanomedicine within tumor based on 68Ga-NaGdF4 probes
@RGD nanoprobes as a model system to establish a synchronous PET/MR imaging strategy for tumor diagnosis. These nanoprobes exhibited suitable radiochemical half-life, and effective tumor-associated targeting, enabling successful PET/MR imaging across multiple tumor models, including hepatoma, renal cancer, and breast cancer in vivo. Notably, this imaging strategy allowed time-resolved visualization of nanoprobe distribution and prolonged retention behavior in orthotopic liver tumors during delayed imaging periods, providing imaging-based insights into nanomedicine pharmacodynamics.
Authors
- Lele Song (ORCID: https://orcid.org/0000-0002-1638-1798)
- Bixiao Cui (ORCID: https://orcid.org/0000-0003-4353-4590)
- Jie Lu (ORCID: https://orcid.org/0000-0003-2581-3414)
- Sitong Wu
- Weiwei Li (ORCID: https://orcid.org/0000-0002-7329-4236)
- Yinghua Zou (ORCID: https://orcid.org/0000-0002-7538-5924)
- Wenpeng Huang
- Qi Yang
- Lei Kang
- Zhao Chen
- Yi Hou
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- China-Japan Friendship Hospital (CN)
- Peking University First Hospital (CN)
- Beijing University of Chemical Technology (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2026-04-01
- DOI
- https://doi.org/10.1186/s12951-026-04325-1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Beijing Nova Program